Description

tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate is a high-value, protected spirocyclic amine building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, serving as a key intermediate in the development of novel pharmaceutical candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A versatile building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic and amine-functionalized scaffold.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component or amine-bearing moiety in the design of bifunctional degraders.
• Agrochemical Synthesis: Intermediate for creating novel active ingredients with spirocyclic motifs for crop protection.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, nitrogen-containing heterocycles.

Basic Information

Product Name	tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1163729-53-0
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	6-[(1,1-Dimethylethoxy)carbonyl]-6-azaspiro[2.5]octane-1-methanamine; 1-(Aminomethyl)-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; tert-Butyl 1-(aminomethyl)-6-azaspiro[2.5]octane-6-carboxylate; 6-Boc-1-(aminomethyl)-6-azaspiro[2.5]octane; Boc-Protected 1-Aminomethyl-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-6-carboxylic acid, 1-(aminomethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(Aminomethyl)-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.