Description

(2S,4R)-4-Hydroxy-2-Methylpyrrolidine-2-Carboxamide is a high-purity chiral pyrrolidine derivative, a key building block in modern pharmaceutical synthesis. Its defined stereochemistry and functional groups make it a critical intermediate for constructing complex molecules with high biological specificity. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and chiral catalysts.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of new drugs, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in asymmetric catalytic reactions to produce enantiomerically pure compounds.
• Chemical Research: Used in academic and industrial R&D for exploring new synthetic methodologies and studying structure-activity relationships (SAR).
• Agrochemical Development: Potential building block for creating novel, stereospecific crop protection agents and pesticides.
• Ligand Synthesis: Can be utilized to develop novel chiral ligands for transition metal catalysis.
• Peptidomimetics: Acts as a constrained, proline-like scaffold in the design of peptide mimics for drug discovery.

Basic Information

Product Name	(2S,4R)-4-Hydroxy-2-Methylpyrrolidine-2-Carboxamide
CAS No.	1163706-91-9
Molecular Formula	C7H14N2O2
Molecular Weight	158.20 g/mol
Synonyms	(2S,4R)-4-Hydroxy-2-methylpyrrolidine-2-carboxamide; 2-Methyl-4-hydroxypyrrolidine-2-carboxamide, (2S,4R)-; (2S,4R)-4-Hydroxy-2-methyl-2-pyrrolidinecarboxamide; 4-Hydroxy-2-methylpyrrolidine-2-carboxamide; (2S,4R)-HMPC; 1163706-91-9; 4-Hydroxy-2-methylpyrrolidine-2-carboxylic acid amide
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Hydroxy-2-Methylpyrrolidine-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.