Description

1-Methanesulfonyl-Pyrrolidine-2-Carboxylic Acid Hydrazide is a high-purity, advanced pharmaceutical intermediate with a distinct sulfonyl-substituted pyrrolidine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic chemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing new drug candidates and specialty molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of protease inhibitors, kinase inhibitors, and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery and lead optimization programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides that incorporate sulfonamide and hydrazide functionalities.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Peptidomimetic Development: The pyrrolidine-carboxylic acid hydrazide structure makes it suitable for creating peptidomimetics and constrained peptide analogs.

Basic Information

Product Name	1-Methanesulfonyl-Pyrrolidine-2-Carboxylic Acid Hydrazide
CAS No.	1163661-09-3
Molecular Formula	C7H15N3O3S
Molecular Weight	221.28 g/mol
Synonyms	1-(Methylsulfonyl)pyrrolidine-2-carbohydrazide; 2-Pyrrolidinecarboxylic acid, 1-(methylsulfonyl)-, hydrazide; 1-Methanesulfonyl-2-pyrrolidinecarboxylic acid hydrazide; 1-(Methanesulfonyl)pyrrolidine-2-carboxylic acid hydrazide; L-Proline, 1-(methylsulfonyl)-, hydrazide; MS-Pyrrolidine-Hydrazide; 1163661-09-3 (CAS Name)
EINECS	Contact for details

Quality Control

Our 1-Methanesulfonyl-Pyrrolidine-2-Carboxylic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.