Description

5-Bromo-3-Fluoro-2-Methylpyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable scaffold for introducing both bromine and fluorine atoms into complex molecular architectures. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated pyridines.
• Material Science Research: Used in the creation of specialty chemicals, liquid crystals, and functional polymers requiring halogenated heterocyclic cores.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromine substituent.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fragment in fragment-based drug discovery (FBDD).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	5-Bromo-3-Fluoro-2-Methylpyridine
CAS No.	1162674-74-9
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	3-Fluoro-5-bromo-2-methylpyridine; 2-Methyl-5-bromo-3-fluoropyridine; 5-Bromo-3-fluoro-2-picoline; Pyridine, 5-bromo-3-fluoro-2-methyl-; 1162674-74-9; 5-Br-3-F-2-MePy
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-2-Methylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.