Description

1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethanone is a high-purity, multi-functional pyridine derivative building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules in pharmaceutical and agrochemical research, offering precise bromine and fluorine substitution points for targeted modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a key precursor in the development of new-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Used in the creation of specialized ligands, organic semiconductors, and photoactive materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Functional Group Transformation: The acetyl (ethanone) group provides a handle for further chemical transformations, including reductions, oxidations, and condensations.

Basic Information

Item	Details
Product Name	1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethanone
CAS No.	1160936-52-6
Molecular Formula	C7H5BrFNO
Molecular Weight	218.03 g/mol
Synonyms	2-Acetyl-5-bromo-3-fluoropyridine; 5-Bromo-3-fluoro-2-acetylpyridine; 1-(5-Bromo-3-fluoropyridin-2-yl)ethan-1-one; 2-Acetyl-3-fluoro-5-bromopyridine; Ethanone, 1-(5-bromo-3-fluoro-2-pyridinyl)-; 5-Bromo-3-fluoro-2-pyridinyl methyl ketone
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.