Description

1-Ethyl-3-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazolo[5,4-B]Pyridin-2-Yl]Urea is a sophisticated heterocyclic organic compound that serves as a key building block in modern synthetic chemistry. Its molecular architecture, featuring a thiazolopyridine core functionalized with a pinacol boronate ester and a urea linkage, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and material science.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient carbon-carbon bond formation, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science & Organic Electronics: Serves as a precursor for creating organic semiconductors, light-emitting materials, and advanced polymers.
• Chemical Biology & Probe Development: Utilized in the design of molecular probes and biochemical tools for studying biological pathways and target engagement.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library production for high-throughput screening.

Basic Information

Product Name	1-Ethyl-3-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazolo[5,4-B]Pyridin-2-Yl]Urea
CAS No.	1160791-16-1
Molecular Formula	C₁₇H₂₃BN₄O₃S
Molecular Weight	374.26 g/mol
Synonyms	1-Ethyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazolo[5,4-b]pyridin-2-yl)urea; 2-[(Ethylcarbamoyl)amino]-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazolo[5,4-b]pyridine; Thiazolo[5,4-b]pyridine-2-carboxamide, N-ethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1160791-16-1; Boronic acid, B-[2-[(ethylamino)carbonyl]amino]thiazolo[5,4-b]pyridin-6-yl]-, 1,1-dimethylethyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazolo[5,4-b]pyridin-2-yl ethylurea
EINECS	Contact for details

Quality Control

Our 1-Ethyl-3-[6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazolo[5,4-B]Pyridin-2-Yl]Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.