Description

4-Amino-3,4-Dihydro-Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and piperidine-based molecular architecture. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and therapeutic agent research. It is primarily sought by R&D chemists, process development scientists, and manufacturers in the global pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for constructing complex molecules with potential therapeutic activity in preclinical and clinical research.
• Medicinal Chemistry & Drug Discovery: Utilized in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes from laboratory to pilot plant and commercial production.
• Contract Research & Manufacturing (CRMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and intermediate supply.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-Amino-3,4-Dihydro-Spiro[2H-1-Benzopyran-2,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1160247-73-3
Molecular Formula	C18H26N2O3
Molecular Weight	318.41 g/mol
Synonyms	tert-Butyl 4-amino-3,4-dihydrospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; 4-Amino-3,4-dihydro-2H-spiro[1-benzopyran-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-4-amino-3,4-dihydrospiro[chromene-2,4'-piperidine]; Boc-4-Amino-spiro[chroman-2,4'-piperidine]; 4-Amino-spiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[chromene-2,4'-piperidine] intermediate; CAS 1160247-73-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under cGMP guidelines where required and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.