Description

Spiro[Isoquinoline-1(2H),4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a key synthetic intermediate for constructing complex molecular architectures, particularly in the discovery of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of potential drug candidates targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those with spirocyclic or fused heterocyclic structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new therapeutic agents.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein interactions.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs) during development phases.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Item	Information
Product Name	Spiro[Isoquinoline-1(2H),4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	1160247-65-3
Molecular Formula	C19H26N2O2
Molecular Weight	314.42 g/mol
Synonyms	tert-Butyl 3,4-dihydrospiro[isoquinoline-1(2H),4'-piperidine]-1'-carboxylate; 1'-Boc-1,2,3,4-tetrahydrospiro[isoquinoline-4,4'-piperidine]; 1,1-Dimethylethyl 3,4-dihydrospiro[isoquinoline-1(2H),4'-piperidine]-1'-carboxylate; Spiro[1,2,3,4-tetrahydroisoquinoline-4,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-1,2,3,4-tetrahydrospiro[isoquinoline-4,4'-piperidine]; Boc-Spiropiperidine-THIQ; tert-Butyl 1,2,3,4-tetrahydrospiro[isoquinoline-4,4'-piperidine]-1'-carboxylate
EINECS	Contact for details

Quality Control

Our Spiro[Isoquinoline-1(2H),4'-Piperidine]-1'-Carboxylic Acid, 3,4-Dihydro-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for advanced R&D and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.