Description

tert-Butyl 7-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for clients.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and pharmacology studies.

Basic Information

Item	Details
Product Name	tert-Butyl 7-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-64-2
Molecular Formula	C18H22BrNO2
Molecular Weight	364.28 g/mol
Synonyms	7-Bromo-1',2',3',4',4a',9a'-hexahydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 7-bromo-1,2,3,4,4a,9a-hexahydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 7-Bromospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; BOC-7-Bromo-spiro(indene-1,4'-piperidine); 1160247-64-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.