Description

tert-Butyl 6-Fluorospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: The spiro[indene-piperidine] core is valuable for creating molecules that target neurological and psychiatric disorders.
• Kinase Inhibitor Synthesis: Serves as a building block for potential oncology treatments targeting specific kinase pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	tert-Butyl 6-Fluorospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-59-5
Molecular Formula	C18H22FNO2
Molecular Weight	303.38 g/mol
Synonyms	1'-BOC-6-Fluorospiro[indene-1,4'-piperidine]; 6-Fluoro-1,4-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-1,4-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; BOC-6-Fluorospiro[Indene-1,4'-Piperidine]; 6-Fluoro-1'-BOC-spiro[indene-1,4'-piperidine]; 1160247-59-5; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of tert-Butyl 6-Fluorospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is analyzed using advanced techniques like HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. We adhere to strict internal quality protocols suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.