Description

tert-Butyl 3-Amino-5-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine-based molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially for neurological and oncological targets.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke molecular entities.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	tert-Butyl 3-Amino-5-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-54-0
Molecular Formula	C19H28N2O2
Molecular Weight	316.44 g/mol
Synonyms	1'-Boc-3-Amino-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 3-amino-5-methyl-2,3-dihydro-1H-spiro[indene-1,4'-piperidine]-1'-carboxylate; 3-Amino-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1H-Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 3-amino-2,3-dihydro-5-methyl-, 1,1-dimethylethyl ester; BOC-3-Amino-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]; 1160247-54-0; Spiro[indene-1,4'-piperidine] intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-5-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with ICH guidelines and supports development under cGMP standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.