Description

tert-Butyl 7-Bromo-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is specifically engineered for use in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and process R&D for central nervous system (CNS) and oncological targets.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of novel drug candidates, especially those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its versatile bromo and carbonyl functional groups.
• API Development for CNS Disorders: A foundational component in the synthetic route for potential therapeutics addressing neurological conditions.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale production for new chemical entities (NCEs).
• Synthesis of Spirocyclic Analogues: The core spiro[indene-1,4'-piperidine] structure makes it a precursor for generating diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 7-Bromo-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-52-8
Molecular Formula	C18H22BrNO3
Molecular Weight	380.28 g/mol
Synonyms	1'-BOC-7-Bromo-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; 7-Bromo-1,3-dihydrospiro[indene-1,4'-piperidin]-3-one 1'-carboxylic acid tert-butyl ester; tert-Butyl 7-bromo-3-oxospiro[indene-1,4'-piperidine]-1'-carboxylate; BOC-7-Bromo-3-oxo-spiro[indane-1,4'-piperidine]; 7-Bromo-3-oxo-2,3-dihydro-1H-spiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of tert-Butyl 7-Bromo-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and results are available upon request. We adhere to cGMP guidelines for the production of pharmaceutical intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.