Description

tert-Butyl 7-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine-based molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily required by research institutions and pharmaceutical development companies engaged in medicinal chemistry and process scale-up.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery pipelines.
• Process Chemistry & Scale-Up: Serves as a standardized building block for optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in API manufacturing.
• Custom Synthesis: A starting material for the contract synthesis of more complex, proprietary molecules for pharmaceutical clients.

Basic Information

Product Name	tert-Butyl 7-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-49-3
Molecular Formula	C19H25NO3
Molecular Weight	315.41 g/mol
Synonyms	1'-Boc-7-Methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 7-methyl-3-oxospiro[2,3-dihydro-1H-indene-1,4'-piperidine]-1'-carboxylate; 7-Methyl-3-oxo-1,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,3-Dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid, 7-methyl-3-oxo-, 1,1-dimethylethyl ester; 1'-Boc-7-methylindanone piperidine; BOC-7-Methyl-3-oxo-Dihydrospiro[indene-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.