Description

tert-Butyl 6-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly within central nervous system (CNS) and metabolic disorder research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• CNS Drug Development: Serves as a core structural component in the research and development of potential treatments for neurological and psychiatric disorders.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Process Chemistry: Utilized in route scouting, scale-up, and process optimization for efficient and cost-effective API manufacturing.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	tert-Butyl 6-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-44-8
Molecular Formula	C19H25NO3
Molecular Weight	315.41 g/mol
Synonyms	1'-Boc-6-methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 6-methyl-3-oxospiro[indene-1,4'-piperidine]-1'-carboxylate; 6-Methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 6-methyl-3-oxo-2,3-dihydrospiro[1H-indene-1,4'-piperidine]-1'-carboxylate; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 6-methyl-3-oxo-2,3-dihydro-, 1,1-dimethylethyl ester; BOC-6-Methyl-3-oxo-spiro[indane-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.