Description

tert-Butyl 5,6-Dimethoxy-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate CAS NO 1160247-33-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of critical importance for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the development of central nervous system (CNS) and other therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis to discover new bioactive molecules.
• Process Development & Scale-up: Employed in the optimization and kilogram-scale production of developmental drugs under cGMP conditions.
• Building Block for Spirocyclic Compounds: Its unique spiro[indenepiperidine] structure makes it valuable for constructing molecules with specific three-dimensional geometries for enhanced receptor binding.

Basic Information

Item	Detail
Product Name	tert-Butyl 5,6-Dimethoxy-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-33-5
Molecular Formula	C20H27NO4
Molecular Weight	345.44 g/mol
Synonyms	1'-Boc-5,6-dimethoxy-2,3-dihydrospiro[indene-1,4'-piperidine]; 5,6-Dimethoxy-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5,6-dimethoxy-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate; Boc-5,6-dimethoxyspiro[indenepiperidine]; Spiro[indenepiperidine] intermediate 1160247-33-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,6-Dimethoxy-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.