Description

tert-Butyl 5-Bromo-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D teams and process chemists in the pharmaceutical and biotechnology industries working on central nervous system (CNS) targets, kinase inhibitors, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile bromo and carbonyl functional groups.
• API Development: Serves as a core scaffold for developing potential active pharmaceutical ingredients with modified pharmacokinetic properties.
• Chemical Biology Probes: Can be utilized to create specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects on behalf of pharmaceutical clients.

Basic Information

Product Name	tert-Butyl 5-Bromo-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
CAS No.	1160247-30-2
Molecular Formula	C18H22BrNO3
Molecular Weight	380.28 g/mol
Synonyms	1'-BOC-5-Bromo-3-oxospiro[indene-1,4'-piperidine]; 5-Bromo-3-oxo-1,3-dihydro-2H-spiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-3-oxospiro[indene-1,4'-piperidine]-1'-carboxylate; 1,3-Dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid, 5-bromo-3-oxo-, 1,1-dimethylethyl ester; BOC-5-Bromospiro[indenepiperidine]one; 5-Bromospiro[indane-1,4'-piperidine]-3-one-1'-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere if long-term storage is required to minimize potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.