Description

tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of complex molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex spirocyclic and piperidine-containing drug candidates.
• CNS Drug Research: Used in the development of potential therapeutics for neurological and psychiatric conditions, leveraging its privileged structural motif.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly those with spiro[indoline-3,4'-piperidine] cores.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for chemical biology studies and the exploration of new synthetic methodologies.

Basic Information

Item	Detail
Product Name	tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride
CAS No.	1160247-22-2
Molecular Formula	C17H23ClN2O2·HCl
Molecular Weight	359.30 g/mol (as hydrochloride salt)
Synonyms	1-Boc-5-Chlorospiro[indoline-3,4'-piperidine] Hydrochloride; tert-Butyl 5-chloro-1,2-dihydrospiro[indole-3,4'-piperidine]-1-carboxylate hydrochloride; 5-Chloro-1-[(tert-butoxy)carbonyl]spiro[indoline-3,4'-piperidine] hydrochloride; 5-Chloro-1-N-Boc-spiro[indoline-3,4'-piperidine] HCl; Boc-5-Chloro-spiro(indoline-3,4'-piperidine) hydrochloride; 1160247-22-2; Spiro[indoline-3,4'-piperidine], 5-chloro-1-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Chlorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation upon exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.