Description

2-Cbz-7-Boc-2,7-Diazaspiro-[4.4]Nonane-4-Carboxylicacid is a sophisticated, multi-protected spirocyclic amino acid derivative, serving as a critical advanced pharmaceutical intermediate for the synthesis of complex bioactive molecules. Its unique diazaspiro[4.4]nonane scaffold provides a rigid, three-dimensional framework essential for modulating the pharmacokinetic and binding properties of drug candidates. This high-purity building block is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for developing novel therapeutics targeting central nervous system disorders and other challenging disease areas.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, especially for CNS-targeted drugs.
• Peptidomimetics Development: The spirocyclic structure serves as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	2-Cbz-7-Boc-2,7-Diazaspiro-[4.4]Nonane-4-Carboxylicacid
CAS No.	1160247-20-0
Molecular Formula	C21H28N2O6
Molecular Weight	404.46 g/mol
Synonyms	2-[(Benzyloxy)carbonyl]-7-[(tert-butoxy)carbonyl]-2,7-diazaspiro[4.4]nonane-4-carboxylic acid; 2-Cbz-7-Boc-2,7-Diazaspiro[4.4]Nonane-4-Carboxylic Acid; 2,7-Diazaspiro[4.4]nonane-4-carboxylic acid, 2-[(phenylmethoxy)carbonyl]-7-[(1,1-dimethylethoxy)carbonyl]-; 2-Cbz-7-Boc-2,7-Diazaspiro[4.4]Nonane-4-Carboxylate; 2,7-Diazaspiro[4.4]nonane-4-carboxylic acid, N2-(benzyloxycarbonyl)-N7-(tert-butoxycarbonyl)-; 1160247-20-0; 2-Cbz-7-Boc-Diazaspiro[4.4]Nonane-4-CA
EINECS	Contact for details

Quality Control

Our 2-Cbz-7-Boc-2,7-Diazaspiro-[4.4]Nonane-4-Carboxylicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.