Description

8-(tert-Butoxycarbonyl)-8-Azaspiro[4.5]Decane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected azaspirocyclic scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with potential therapeutic activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the production of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its rigid, three-dimensional spirocyclic structure.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) requiring a protected amine functionality.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening to create diverse compound libraries for biological testing.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for commercial pharmaceutical manufacturing.

Basic Information

Product Name	8-(tert-Butoxycarbonyl)-8-Azaspiro[4.5]Decane-2-Carboxylic Acid
CAS No.	1160247-17-5
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	8-(Boc)-8-Azaspiro[4.5]decane-2-carboxylic acid; 8-[(1,1-Dimethylethoxy)carbonyl]-8-azaspiro[4.5]decane-2-carboxylic acid; 8-Boc-8-azaspiro[4.5]decane-2-carboxylic acid; tert-Butyl 2-carboxy-8-azaspiro[4.5]decane-8-carboxylate; 8-Azaspiro[4.5]decane-2-carboxylic acid, 8-[(1,1-dimethylethoxy)carbonyl]-; Boc-8-azaspiro[4.5]decane-2-carboxylic acid; 1160247-17-5
EINECS	Contact for details

Quality Control

Our 8-(tert-Butoxycarbonyl)-8-Azaspiro[4.5]Decane-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if opened for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.