Description

tert-Butyl 1-Carbamoyl-6-Azaspiro[2.5]Octane-6-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of complex active pharmaceutical ingredients (APIs).

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new drug molecules, especially those containing the 6-azaspiro[2.5]octane pharmacophore.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities for various disease targets.
• Protease Inhibitor Research: The spirocyclic structure is valuable in the design and synthesis of inhibitors for proteolytic enzymes.
• Chemical Biology Probes: Employed in the creation of specialized molecular tools for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of clinical trial materials.
• Academic Research: Used in university and institutional laboratories for advanced organic synthesis methodology and novel heterocycle chemistry.

Basic Information

Product Name	tert-Butyl 1-Carbamoyl-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1160247-14-2
Molecular Formula	C13H22N2O3
Molecular Weight	254.33 g/mol
Synonyms	6-[(tert-Butoxy)carbonyl]-6-azaspiro[2.5]octane-1-carboxamide; 1-Carbamoyl-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; tert-Butyl 1-carbamoyl-6-azaspiro[2.5]octane-6-carboxylate; 6-Boc-6-azaspiro[2.5]octane-1-carboxamide; Boc-6-azaspiro[2.5]octane-1-carboxamide; 6-Azaspiro[2.5]octane-1-carboxamide, 6-[(1,1-dimethylethoxy)carbonyl]-; 1160247-14-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Carbamoyl-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development from milligram to kilogram scale with consistent quality, adhering to cGMP principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.