Description

8-(1,1-Dimethylethyl) 2-Methyl 1-Oxa-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, particularly those targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Serves as a key scaffold for developing new generation pesticides and herbicides with enhanced efficacy and selectivity.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing novel spirocyclic and heterocyclic compounds for material science and catalysis.
• Medicinal Chemistry Research: Employed in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its three-dimensional, rigid framework.
• Process Chemistry Development: Used in scaling up synthetic routes for APIs, where its defined purity and consistency are crucial for yield and regulatory compliance.

Basic Information

Product Name	8-(1,1-Dimethylethyl) 2-Methyl 1-Oxa-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate
CAS No.	1160246-95-6
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	tert-Butyl 2-methyl-1-oxa-8-azaspiro[4.5]decane-2,8-dicarboxylate; 1-Oxa-8-azaspiro[4.5]decane-2,8-dicarboxylic acid, 8-(1,1-dimethylethyl) 2-methyl ester; 2-Methyl 8-tert-butyl 1-oxa-8-azaspiro[4.5]decane-2,8-dicarboxylate; Spirocyclic ester intermediate 1160246-95-6
EINECS	Contact for details

Quality Control

Our production of 8-(1,1-Dimethylethyl) 2-Methyl 1-Oxa-8-Azaspiro[4.5]Decane-2,8-Dicarboxylate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.