Description

8-(tert-Butoxycarbonyl)-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry & Lead Optimization: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Peptidomimetic & Scaffold Development: Its spirocyclic structure is valuable for constructing conformationally restricted scaffolds and peptidomimetics in drug design.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential active pharmaceutical ingredients (APIs).
• Academic & Industrial Research: A valuable reagent for universities and contract research organizations (CROs) engaged in synthetic organic chemistry and pharmacology projects.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized intermediates under cGMP conditions.

Basic Information

Product Name	8-(tert-Butoxycarbonyl)-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid
CAS No.	1160246-88-7
Molecular Formula	C14H23NO5
Molecular Weight	285.34 g/mol
Synonyms	1-Oxa-8-azaspiro[4.5]decane-2-carboxylic acid, 8-[(1,1-dimethylethoxy)carbonyl]-; Boc-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid; 8-Boc-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid; tert-Butyl 2-carboxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-(Boc)-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid; 8-N-Boc-1-oxa-8-azaspiro[4.5]decane-2-carboxylic acid; 1160246-88-7
EINECS	Contact for details

Quality Control

Our production of 8-(tert-Butoxycarbonyl)-1-Oxa-8-Azaspiro[4.5]Decane-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized and tested using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.