Description

tert-Butyl 3-Oxo-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic lactam class. This compound is a critical building block in modern medicinal chemistry, valued for its unique structural framework that enables the synthesis of complex, bioactive molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and metabolic disorder research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing spirocyclic and fused heterocyclic compounds during lead optimization and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of novel protease inhibitors due to its lactam moiety.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity intermediates.

Basic Information

Item	Details
Product Name	tert-Butyl 3-Oxo-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate
CAS No.	1160246-85-4
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	7-Boc-3-oxo-1-oxa-7-azaspiro[4.4]nonane; tert-Butyl 3-oxo-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; 1-Oxa-7-azaspiro[4.4]nonane-3-one, 7-(1,1-dimethylethyl) ester; 7-(tert-Butoxycarbonyl)-1-oxa-7-azaspiro[4.4]nonan-3-one; Boc-1-oxa-7-azaspiro[4.4]nonan-3-one; 1160246-85-4; 3-Oxo-1-oxa-7-azaspiro[4.4]nonane-7-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Oxo-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the exacting standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.