Description

1-Oxa-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(Iodomethyl)-, 1,1-Dimethylethyl Ester is a sophisticated spirocyclic building block featuring a reactive iodomethyl group, making it a valuable intermediate for advanced organic synthesis. This compound is critical for medicinal chemistry research, enabling the construction of complex molecular architectures with high precision. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile spirocyclic scaffold and reactive handle.
• Chemical Biology: Serves as a precursor for probes and ligands targeting specific enzymes or receptors.
• Peptidomimetics: Incorporation into peptide analogs to enhance metabolic stability and bioavailability.
• Agrochemical Research: Intermediate in the development of new crop protection agents with complex ring systems.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and the exploration of new chemical spaces.

Basic Information

Product Name	1-Oxa-7-Azaspiro[3.5]Nonane-7-Carboxylic Acid, 2-(Iodomethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1160246-84-3
Molecular Formula	C13H22INO3
Molecular Weight	367.22 g/mol
Synonyms	tert-Butyl 2-(iodomethyl)-1-oxa-7-azaspiro[3.5]nonane-7-carboxylate; 7-Boc-2-(iodomethyl)-1-oxa-7-azaspiro[3.5]nonane; 2-(Iodomethyl)-1-oxa-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester; 1-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 2-(iodomethyl)-, 1,1-dimethylethyl ester; Boc-protected iodomethyl spirocyclic ether; Spirocyclic Boc-amino ether iodide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, related substances, and residual solvents are available upon request. We adhere to cGMP principles for the manufacture of pharmaceutical intermediates to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.