Description

2,6-Diazaspiro[4.5]Decane-6-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and diaza structure. This compound is of significant value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Process Chemistry & Scale-Up: Serves as a defined starting material for the GMP-compliant synthesis of active pharmaceutical ingredients (APIs) during clinical and commercial manufacturing.
• Protease Inhibitor Synthesis: The diazaspiro core is a valuable motif in the design of inhibitors for various enzymes, including proteases relevant to virology and other disease pathways.
• Chemical Biology & Probe Development: Utilized in the creation of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity, complex intermediates.

Basic Information

Product Name	2,6-Diazaspiro[4.5]Decane-6-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1160246-75-2
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	tert-Butyl 3-oxo-2,6-diazaspiro[4.5]decane-6-carboxylate; 2,6-Diazaspiro[4.5]decane-6-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; 6-(tert-Butoxycarbonyl)-2,6-diazaspiro[4.5]decan-3-one; Boc-2,6-diazaspiro[4.5]decan-3-one; 3-Oxo-2,6-diazaspiro[4.5]decane-6-carboxylic acid tert-butyl ester; 1160246-75-2; tert-Butyl 3-oxo-2,6-diazaspiro[4.5]decane-6-carboxylate
EINECS	Contact for details

Quality Control

Our production of 2,6-Diazaspiro[4.5]Decane-6-Carboxylic Acid, 3-Oxo-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS). A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.