Description

1-[(tert-Butoxy)Carbonyl]-Alpha,3-Dioxo-4-Piperidineacetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate of significant synthetic utility. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and process chemistry optimization.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially protease inhibitors and other neurologically active compounds.
• API Synthesis: Serves as a key building block for constructing the piperidine core structure found in numerous Active Pharmaceutical Ingredients (APIs).
• Process Chemistry & R&D: Used in laboratory-scale research and process development for route scouting and optimization of final drug substances.
• Peptidomimetic Chemistry: Employed in the design and synthesis of peptide analogs and mimetics due to its functionalized heterocyclic scaffold.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Product Name	1-[(tert-Butoxy)Carbonyl]-Alpha,3-Dioxo-4-Piperidineacetic Acid Methyl Ester
CAS No.	1159983-63-7
Molecular Formula	C14H21NO6
Molecular Weight	299.32 g/mol
Synonyms	1-Boc-α,3-dioxo-4-piperidineacetic acid methyl ester; Methyl 1-[(tert-butoxy)carbonyl]-α,3-dioxo-4-piperidineacetate; 1-(tert-Butoxycarbonyl)-α,3-dioxopiperidine-4-acetic acid methyl ester; 4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-α,3-dioxo-, methyl ester; Methyl 1-Boc-α,3-dioxo-4-piperidineacetate; 1-Boc-4-(methoxycarbonylmethyl)-2,6-dioxopiperidine; Boc-DOAP-OMe
EINECS	Contact for details

Quality Control

Our 1-[(tert-Butoxy)Carbonyl]-Alpha,3-Dioxo-4-Piperidineacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.