Description

Rac n-Boc-Anatabine is a protected derivative of the minor tobacco alkaloid anatabine, featuring a racemic mixture and a tert-butoxycarbonyl (Boc) protecting group on the secondary amine. This compound serves as a crucial chemical intermediate and research standard in advanced organic synthesis and pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for developing novel therapeutics and exploring nicotinic acetylcholine receptor interactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting neurological pathways.
• Biochemical Research: Reference standard and precursor in studies investigating nicotinic acetylcholine receptor (nAChR) activity and modulation.
• Organic Synthesis: Protected amine synthon for constructing complex alkaloid analogs and heterocyclic compounds in medicinal chemistry.
• Academic Research: Tool compound for studying the structure-activity relationships (SAR) of anatabine derivatives.
• Process Development: Used in scaling up and optimizing synthetic routes for GMP-grade active pharmaceutical ingredients (APIs).
• Analytical Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and NMR methods in quality control laboratories.

Basic Information

Product Name	Rac n-Boc-Anatabine
CAS No.	1159977-12-4
Molecular Formula	C₁₅H₂₂N₂O₂
Molecular Weight	262.35 g/mol
Synonyms	rac-tert-Butyl (E)-3-(1,2,3,6-tetrahydropyridin-2-yl)pyridin-1-ylcarbamate; (±)-N-Boc-Anatabine; 1-Boc-1,2,3,6-Tetrahydro-2,3'-bipyridine; Anatabine N-Boc derivative; tert-Butyl (E)-3-(1,2,3,6-tetrahydropyridin-2-yl)pyridine-1-carboxylate; rac-1-(tert-Butoxycarbonyl)anatabine; BOC-Anatabine (racemic)
EINECS	Contact for details

Quality Control

Our Rac n-Boc-Anatabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.