Description

2,8-Diazaspiro[4.5]Decane, 8-(Phenylmethyl)-, Hydrochloride (1:2) is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• API Development: Serves as a core structural unit in the development of new Active Pharmaceutical Ingredients (APIs), especially for receptor modulators.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Biochemical Tool Compound: May be used in academic and industrial research as a probe to study biological pathways and enzyme interactions.
• Fine Chemical Synthesis: Employed in the synthesis of other complex, high-value specialty chemicals beyond pharmaceuticals.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decane, 8-(Phenylmethyl)-, Hydrochloride (1:2)
CAS No.	1159826-27-3
Molecular Formula	C15H22N2 · 2HCl
Molecular Weight	311.27 g/mol (Free base: 230.35 g/mol)
Synonyms	8-Benzyl-2,8-diazaspiro[4.5]decane dihydrochloride; 8-Benzyl-2,8-diazaspiro[4.5]decane hydrochloride (1:2); 8-(Phenylmethyl)-2,8-diazaspiro[4.5]decane dihydrochloride; 2,8-Diazaspiro[4.5]decane, 8-benzyl-, dihydrochloride; Spiro[4.5]decane-8-benzyl-2,8-diazonium chloride; CAS 1159826-27-3
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decane, 8-(Phenylmethyl)-, Hydrochloride (1:2) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.