Description

tert-Butyl 4-(4-Bromo-2-Fluorobenzoyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with halogenated aromatic substitution. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of complex bioactive molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Protease Inhibitor Development: Serves as a core scaffold for designing and synthesizing potential protease inhibitors.
• Kinase Inhibitor Synthesis: Employed in the construction of kinase inhibitor libraries for targeted cancer therapies.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects and scale-up under cGMP conditions.

Basic Information

Product Name	tert-Butyl 4-(4-Bromo-2-Fluorobenzoyl)Piperidine-1-Carboxylate
CAS No.	1159826-04-6
Molecular Formula	C17H21BrFNO3
Molecular Weight	386.26 g/mol
Synonyms	1-Boc-4-(4-Bromo-2-fluorobenzoyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(4-bromo-2-fluorobenzoyl)piperidine; 4-(4-Bromo-2-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(4-bromo-2-fluorobenzoyl)-1-piperidinecarboxylate; N-Boc-4-(4-Bromo-2-fluorobenzoyl)piperidine; 1-N-Boc-4-(4-Bromo-2-fluorobenzoyl)piperidine; 4-(4-Bromo-2-fluorobenzoyl)piperidine-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(4-Bromo-2-Fluorobenzoyl)Piperidine-1-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.