Description

(5,6,7,8-Tetrahydro-[1,8]Naphthyridin-2-Yl)-Acetic Acid Methyl Ester 2Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its fused bicyclic naphthyridine structure. This compound matters as a critical building block in medicinal chemistry, enabling the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug molecules, especially those with naphthyridine-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and scale-up activities.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and novel heterocycle development.

Basic Information

Product Name	(5,6,7,8-Tetrahydro-[1,8]Naphthyridin-2-Yl)-Acetic Acid Methyl Ester 2Hcl
CAS No.	1159823-05-8
Molecular Formula	C12H18N2O2 • 2HCl
Molecular Weight	295.20 g/mol (Free base: 222.28 g/mol)
Synonyms	Methyl (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate dihydrochloride; 2-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)-acetic acid methyl ester hydrochloride; 1,8-Naphthyridine-2-acetic acid, 5,6,7,8-tetrahydro-, methyl ester, dihydrochloride; Methyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate dihydrochloride; CAS 1159823-05-8
EINECS	Contact for details

Quality Control

Our (5,6,7,8-Tetrahydro-[1,8]Naphthyridin-2-Yl)-Acetic Acid Methyl Ester 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.