Description

2-Bromo-5-(Tetrahydropyran-4-Yl)Pyridine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a halogenated pyridine ring and a tetrahydropyran moiety, enabling precise molecular construction for complex target molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of small molecule drug candidates, particularly for kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, where the pyridine and tetrahydropyran structures contribute to biological activity.
• Ligand Synthesis: Acts as a versatile scaffold for constructing sophisticated ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Library Synthesis: A key building block for creating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	2-Bromo-5-(Tetrahydropyran-4-Yl)Pyridine
CAS No.	1159817-81-8
Molecular Formula	C10H12BrNO
Molecular Weight	242.11 g/mol
Synonyms	2-Bromo-5-(tetrahydro-2H-pyran-4-yl)pyridine; 5-(Oxan-4-yl)-2-bromopyridine; 2-Bromo-5-(4-tetrahydropyranyl)pyridine; Pyridine, 2-bromo-5-(tetrahydro-2H-pyran-4-yl)-; 2-Bromo-5-(tetrahydropyran-4-yl)pyridine; 1159817-81-8; 4-(6-Bromopyridin-3-yl)tetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Tetrahydropyran-4-Yl)Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.