Description

(Z)-Pitavastatin Calcium Salt is a specific stereoisomer of the potent HMG-CoA reductase inhibitor, Pitavastatin. This compound is of significant interest in pharmaceutical research and development for its potential as a reference standard or an intermediate in the synthesis of novel statin-based therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug discovery, metabolic disorder research, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories.
• Metabolic Research: Serves as a key biochemical tool for studying cholesterol biosynthesis pathways and HMG-CoA reductase enzyme kinetics.
• Drug Discovery Intermediate: Acts as a critical building block or precursor in the synthesis of new statin analogs and prodrugs.
• Impurity Profiling: Employed as an identified impurity standard to monitor and control the stereochemical purity of Pitavastatin active pharmaceutical ingredient (API) batches.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and investigating structure-activity relationships (SAR) of statins.

Basic Information

Item	Detail
Product Name	(Z)-Pitavastatin Calcium Salt
CAS No.	1159588-21-2
Molecular Formula	C50H54CaF2N2O8 • xH2O
Molecular Weight	Contact for details
Synonyms	(Z)-Pitavastatin Calcium; Pitavastatin (Z)-Isomer Calcium Salt; (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic Acid Calcium Salt (Z-isomer); Livalo Impurity (Z-isomer); NK-104 (Z-isomer) Calcium Salt
EINECS	Contact for details

Quality Control

Our (Z)-Pitavastatin Calcium Salt is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.