Description

(R)-2-((tert-Butoxycarbonyl)Amino)-3-(Diethoxyphosphoryl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a phosphonate group, making it a critical chiral building block for advanced synthesis. Its primary value lies in enabling the precise construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This product is essential for researchers and manufacturers in pharmaceutical R&D, peptide chemistry, and medicinal chemistry who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other biologically active molecules.
• Peptidomimetic Research: Used to incorporate phosphonate isosteres into peptide backbones, creating metabolically stable analogs for drug design.
• Organocatalyst and Ligand Precursor: Serves as a starting material for synthesizing chiral phosphonate-based catalysts and ligands for asymmetric synthesis.
• Chemical Biology Probes: Employed in the development of activity-based probes and enzyme inhibitors to study biological pathways.
• Agrochemical Synthesis: Intermediate for creating novel chiral compounds with potential herbicidal or insecticidal activity.
• Material Science: Potential monomer or additive for specialized polymers where the phosphonate group imparts specific properties like metal chelation.

Basic Information

Product Name	(R)-2-((tert-Butoxycarbonyl)Amino)-3-(Diethoxyphosphoryl)Propanoic Acid
CAS No.	1159501-66-2
Molecular Formula	C12H24NO7P
Molecular Weight	325.30 g/mol
Synonyms	Boc-DL-Phosphoalanine; (R)-2-((Boc)Amino)-3-(Diethoxyphosphoryl)propanoic Acid; (R)-N-Boc-3-(Diethoxyphosphoryl)alanine; (R)-3-(Diethoxyphosphoryl)-2-((tert-butoxycarbonyl)amino)propanoic Acid; N-(tert-Butoxycarbonyl)-3-(diethoxyphosphoryl)-D-alanine; D-Boc-3-(Diethoxyphosphoryl)alanine; (R)-Boc-NH-CH(CO2H)-CH2-PO(OEt)2; Boc-D-PhosphoAla-OH
EINECS	Contact for details

Quality Control

Our (R)-2-((tert-Butoxycarbonyl)Amino)-3-(Diethoxyphosphoryl)Propanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with standards expected for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.