Description

Methyl 4-(Difluoromethoxy)-3-Hydroxybenzoate is a high-purity synthetic organic intermediate characterized by its difluoromethoxy and hydroxybenzoate ester functional groups. This compound is of significant commercial interest for its role in the development of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where its unique fluorine-containing moiety can enhance metabolic stability and bioavailability. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for synthesis and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, oncology, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoromethoxy group can improve pesticidal activity and environmental profile.
• Chemical Research: Serves as a versatile precursor for further chemical transformations, including hydrolysis, coupling reactions, and fluorination studies in academic and industrial R&D laboratories.
• Liquid Crystal & Material Science: Potential intermediate for the synthesis of fluorinated organic compounds used in advanced materials, such as liquid crystal displays (LCDs) and specialty polymers.

Basic Information

Product Name	Methyl 4-(Difluoromethoxy)-3-Hydroxybenzoate
CAS No.	1159429-52-3
Molecular Formula	C9H8F2O4
Molecular Weight	218.16 g/mol
Synonyms	3-Hydroxy-4-(difluoromethoxy)benzoic acid methyl ester; Methyl 3-hydroxy-4-(difluoromethoxy)benzoate; Benzoic acid, 3-hydroxy-4-(difluoromethoxy)-, methyl ester; 4-(Difluoromethoxy)-3-hydroxy-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(Difluoromethoxy)-3-Hydroxybenzoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.