Description

5-Bromo-3-Chloro-2-Iodo-Pyridine is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique substitution pattern offers multiple orthogonal reactive sites, enabling precise and sequential functionalization for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogen handles for structure-activity relationship (SAR) studies.
• Material Science Building Block: Employed in the creation of functionalized ligands for catalysis, organic electronic materials, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Serves as an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi) due to the differential reactivity of its bromo, chloro, and iodo substituents.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Bromo-3-Chloro-2-Iodo-Pyridine
CAS No.	1159186-43-2
Molecular Formula	C5H2BrClIN
Molecular Weight	318.34 g/mol
Synonyms	2-Iodo-5-bromo-3-chloropyridine; 3-Chloro-5-bromo-2-iodopyridine; 5-Bromo-3-chloro-2-iodopyridine; Pyridine, 5-bromo-3-chloro-2-iodo-; 2-Iodo-3-chloro-5-bromopyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Chloro-2-Iodo-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with ISO, GMP, and REACH standards where applicable, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC-MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.