Description

5-(2-(Trifluoromethyl)Phenyl)Picolinic Acid is a high-value, multi-functional organic building block characterized by its unique aromatic structure containing both a picolinic acid moiety and a trifluoromethylphenyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structural motifs can impart desirable properties like metabolic stability and enhanced binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor programs and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its rigid, fluorinated aromatic structure.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	5-(2-(Trifluoromethyl)Phenyl)Picolinic Acid
CAS No.	1158763-52-0
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	5-[2-(Trifluoromethyl)phenyl]pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-[2-(trifluoromethyl)phenyl]-; 5-(2-Trifluoromethylphenyl)picolinic acid; 5-(α,α,α-Trifluoro-o-tolyl)picolinic acid; 2-Carboxy-5-(2-trifluoromethylphenyl)pyridine; Picolinic acid, 5-(2-(trifluoromethyl)phenyl)-; CAS 1158763-52-0
EINECS	Contact for details

Quality Control

Our 5-(2-(Trifluoromethyl)Phenyl)Picolinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.