Description

1-Pyrrolidinecarboxylic Acid, 3-Amino-3-Methyl-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative belonging to the pyrrolidine class, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, Boc-protected amino group that enables precise control over molecular architecture and stereochemistry in complex chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where structural integrity and purity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and other small molecule therapeutics.
• Peptidomimetics Research: Used to construct non-natural amino acid residues in peptide analogs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the development of advanced pesticides and herbicides that require specific stereochemical configurations for optimal activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring high-fidelity, multi-step organic reactions.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-Amino-3-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	1158758-59-8
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylate; 3-Amino-3-methylpyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-amino-3-methylpyrrolidine; 1-Boc-3-amino-3-methylpyrrolidine; 3-Methyl-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester; (3-Amino-3-methyl-1-pyrrolidinyl)-1,1-dimethylethyl formate; 3-Amino-3-methyl-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidinecarboxylic Acid, 3-Amino-3-Methyl-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment. We operate under a quality management system aligned with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.