Description

1-(tert-Butoxycarbonyl)-4-(2-Methoxyphenyl)Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carboxylic acid core with protective and aromatic substituents. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering precise structural control for medicinal chemists. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and other specialty drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• API Synthesis: Used in multi-step synthesis for constructing complex molecular architectures in active pharmaceutical ingredients.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for producing bespoke compounds for client projects.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-4-(2-Methoxyphenyl)Piperidine-4-Carboxylic Acid
CAS No.	1158750-81-2
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	1-Boc-4-(2-Methoxyphenyl)piperidine-4-carboxylic acid; 4-(2-Methoxyphenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid; 1-N-Boc-4-(2-methoxyphenyl)isonipecotic acid; 4-(2-Methoxyphenyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; tert-Butyl 4-(2-methoxyphenyl)-4-(carboxy)piperidine-1-carboxylate; Boc-4-(2-Methoxyphenyl)piperidine-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-4-(2-Methoxyphenyl)Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.