Description

3-Pyridinecarboxamide, 2-Chloro-n-[4-(1-Cyanocyclopentyl)Phenyl] is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D departments and fine chemical manufacturers need this material to develop next-generation drug candidates, where its specific substitution pattern enables precise pharmacological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of investigational new drugs, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its pyridine core for bioactivity.
• Material Science: Acts as a specialty monomer or ligand in the creation of functional polymers and metal-organic frameworks (MOFs) for catalytic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry programs and structure-activity relationship (SAR) studies.
• Chemical Synthesis: Utilized as a versatile synthon for introducing the 2-chloropyridine-3-carboxamide moiety into more complex molecular architectures.

Basic Information

Product Name	3-Pyridinecarboxamide, 2-Chloro-n-[4-(1-Cyanocyclopentyl)Phenyl]
CAS No.	1158560-99-6
Molecular Formula	C18H16ClN3O
Molecular Weight	325.79 g/mol
Synonyms	2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]pyridine-3-carboxamide; 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]nicotinamide; 2-Chloronicotinamide Derivative; 1158560-99-6; AGN-PC-0K6PJX; AKOS040750623; ZINC000253849996; CS-0476222
EINECS	Contact for details

Quality Control

Our production of 3-Pyridinecarboxamide, 2-Chloro-n-[4-(1-Cyanocyclopentyl)Phenyl] adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to meet the exacting standards of pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.