Description

3-(Trifluoromethyl)-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyrrolopyridine core and trifluoromethyl group. This compound is valued for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug candidate libraries.
• Kinase Inhibitor Synthesis: Serves as a core scaffold in the design and synthesis of potent kinase inhibitors for oncology applications.
• CNS Drug Discovery: Employed in the research and development of novel compounds for neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological mechanisms and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	3-(Trifluoromethyl)-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine Hydrochloride
CAS No.	1158357-67-5
Molecular Formula	C9H8ClF3N2
Molecular Weight	236.62 g/mol
Synonyms	3-(Trifluoromethyl)-5,6,7,8-tetrahydropyrrolo[3,4-b]pyridine hydrochloride; 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine, 3-(trifluoromethyl)-, hydrochloride; 3-Trifluoromethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine HCl; 1158357-67-5; Pyrrolo[3,4-b]pyridine, 6,7-dihydro-3-(trifluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.