Description

2-(3,4-Difluorophenoxy)-5-Fluoronicotinic Acid is a high-purity fluorinated nicotinic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex, biologically active molecules, particularly in the development of novel therapeutic agents. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated aromatic systems into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the difluorophenoxy moiety can contribute to enhanced biological activity and environmental profile.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis and material science, leveraging its aromatic fluorine atoms for electronic tuning.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(3,4-Difluorophenoxy)-5-Fluoronicotinic Acid
CAS No.	1157093-09-8
Molecular Formula	C12H6F3NO3
Molecular Weight	269.18 g/mol
Synonyms	5-Fluoro-2-(3,4-difluorophenoxy)nicotinic acid; 2-(3,4-Difluorophenoxy)-5-fluoropyridine-3-carboxylic acid; Nicotinic acid, 5-fluoro-2-(3,4-difluorophenoxy)-; 1157093-09-8; 2-(3,4-Difluorophenoxy)-5-fluoro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(3,4-Difluorophenoxy)-5-Fluoronicotinic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS, to ensure high purity and consistency that meets the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.