Description

2-Bromo-5-Fluoro-4-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl structures.
• Chemical Biology & Medicinal Chemistry: Employed in fragment-based drug discovery and as a probe molecule for studying protein-ligand interactions due to its distinct halogen bonding capabilities.

Basic Information

Product Name	2-Bromo-5-Fluoro-4-(Trifluoromethyl)Pyridine
CAS No.	1156542-30-1
Molecular Formula	C6H2BrF4N
Molecular Weight	243.99 g/mol
Synonyms	4-(Trifluoromethyl)-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromo-4-(trifluoromethyl)pyridine; 2-Bromo-5-fluoro-4-trifluoromethylpyridine; Pyridine, 2-bromo-5-fluoro-4-(trifluoromethyl)-; 1156542-30-1; 2-Br-5-F-4-CF3-Pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.