Description

5-Chloro-4-(Trifluoromethyl)Picolinonitrile is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique structure, featuring a chloro, trifluoromethyl, and nitrile group on a pyridine core, makes it a critical intermediate for introducing specific pharmacophores and agrochemical motifs. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Material Science Research: Used in the synthesis of specialized ligands, functionalized polymers, and advanced organic electronic materials.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds and molecular probes for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring this precise chemical scaffold.

Basic Information

Product Name	5-Chloro-4-(Trifluoromethyl)Picolinonitrile
CAS No.	1156542-28-7
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	5-Chloro-4-(trifluoromethyl)pyridine-2-carbonitrile; 2-Cyano-5-chloro-4-(trifluoromethyl)pyridine; 5-Chloro-4-trifluoromethylpicolinonitrile; 5-Chloro-4-(trifluoromethyl)-2-pyridinecarbonitrile; 2-Pyridinecarbonitrile, 5-chloro-4-(trifluoromethyl)-; 1156542-28-7
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-4-(Trifluoromethyl)Picolinonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.