Description

Fmoc-Gln(Trt)-Bt CAS NO 1155875-65-2 is a protected amino acid derivative, specifically an Fmoc-protected glutamine side-chain tritylated with a benzotriazole ester activator. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and high-purity incorporation of glutamine residues into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require reliable, high-quality reagents for producing therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise construction of peptides, particularly for incorporating glutamine.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a precursor for creating peptide-protein conjugates or peptide-labeled molecules for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to generate diverse peptide structures for screening.
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Gln(Trt)-Bt
CAS No.	1155875-65-2
Molecular Formula	C46H39N5O5
Molecular Weight	741.84 g/mol
Synonyms	Fmoc-Gln(Trt)-OBt; N-α-Fmoc-N-γ-trityl-L-glutamine benzotriazolyl ester; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}-2-{[(trityl)amino]carbonyl}ethyl)amino)-1-oxo-3-phenyl-2-propenyl benzotriazole-1-carboxylate; Fmoc-Glutamine(Trt)-OBt ester; N-Fmoc-N'-trityl-L-glutamine O-benzotriazolyl ester; Fmoc-L-Gln(Trt)-OBt; Fmoc-Gln(Trt)-OBBt
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Trt)-Bt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.