Description

2-Pyridinecarbonitrile, 4-Chloro-3-Fluoro- is a high-value, halogenated pyridine derivative serving as a critical synthetic intermediate. Its molecular structure, featuring both chloro and fluoro substituents on the pyridine ring, makes it an essential building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyridine core.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for heterocyclic and medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Ligand Synthesis: Used to prepare sophisticated chelating ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Pyridinecarbonitrile, 4-Chloro-3-Fluoro-
CAS No.	1155847-43-0
Molecular Formula	C6H2ClFN2
Molecular Weight	156.55 g/mol
Synonyms	4-Chloro-3-fluoro-2-cyanopyridine; 4-Chloro-3-fluoropicolinonitrile; 3-Fluoro-4-chloropyridine-2-carbonitrile; 2-Cyano-4-chloro-3-fluoropyridine; 4-Chloro-3-fluoro-2-pyridinecarbonitrile; Picolinonitrile, 4-chloro-3-fluoro-; 1155847-43-0
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Each batch of 4-Chloro-3-fluoro-2-cyanopyridine is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.