Description

6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid is a high-value, multifunctional piperidine derivative characterized by its trifluoromethyl group and carboxylic acid functionality. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering unique steric and electronic properties that are highly sought after in modern chemical development. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease drug candidates.
• Agrochemical Synthesis: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique structural motifs.
• Chemical Biology & Proteomics: Acts as a building block for designing molecular probes, enzyme inhibitors, and other tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid
CAS No.	1155103-14-2
Molecular Formula	C7H10F3NO2
Molecular Weight	197.16 g/mol
Synonyms	3-Piperidinecarboxylic acid, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)nipecotic Acid; (R/S)-6-(Trifluoromethyl)piperidine-3-carboxylic acid; 6-Trifluoromethyl-3-piperidinecarboxylic acid; 1155103-14-2; 6-(Trifluoromethyl)-3-piperidinecarboxylic acid; 3-Carboxy-6-(trifluoromethyl)piperidine
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.