Description

Methyl 5-Bromo-2-Fluoro-3-Nitrobenzoate CAS NO 1154278-17-7 is a high-purity, multi-functional aromatic ester building block designed for advanced organic synthesis. This compound is valued for its precise molecular architecture, which facilitates the efficient construction of complex molecules in research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for use as a key intermediate in the synthesis of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the bromo and nitro substituents for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for biochemical and diagnostic research.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki and Buchwald-Hartwig couplings.
• Nitration & Fluorination Studies: Acts as a model compound for studying regioselective aromatic substitution reactions in academic and industrial R&D.

Basic Information

Product Name	Methyl 5-Bromo-2-Fluoro-3-Nitrobenzoate
CAS No.	1154278-17-7
Molecular Formula	C8H5BrFNO4
Molecular Weight	278.03 g/mol
Synonyms	5-Bromo-2-fluoro-3-nitrobenzoic acid methyl ester; Methyl 5-bromo-2-fluoro-3-nitrobenzoate; Benzoic acid, 5-bromo-2-fluoro-3-nitro-, methyl ester; 5-Bromo-2-fluoro-3-nitro methyl benzoate; Methyl ester of 5-bromo-2-fluoro-3-nitrobenzoic acid; 1154278-17-7; MFCD28424728
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-Fluoro-3-Nitrobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to store under an inert atmosphere for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.