Description

5-(Trifluoromethylsulfanyl)Pyridin-2-Amine CAS NO 1153767-57-7 is a high-value pyridine derivative featuring a trifluoromethylthio (-SCF₃) functional group, a motif of significant interest in modern medicinal and agrochemical chemistry. This compound serves as a critical building block for introducing lipophilicity and metabolic stability into target molecules, directly addressing the need for more potent and selective active ingredients. It is primarily sought by R&D and process development teams in the pharmaceutical and crop protection industries for the synthesis of novel drug candidates and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the -SCF₃ group enhances bioactivity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty chemicals and functional materials, such as ligands for catalysis or components for organic electronics.
• Chemical Biology & Proteomics: Acts as a versatile building block for creating chemical probes and tool compounds to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	5-(Trifluoromethylsulfanyl)Pyridin-2-Amine
CAS No.	1153767-57-7
Molecular Formula	C₆H₅F₃N₂S
Molecular Weight	194.18 g/mol
Synonyms	2-Amino-5-(trifluoromethylthio)pyridine; 5-(Trifluoromethylthio)pyridin-2-amine; 2-Pyridinamine, 5-[(trifluoromethyl)thio]-; 5-(Trifluoromethylsulfanyl)-2-pyridinamine; 5-(Trifluoromethylmercapto)pyridin-2-amine; 5-SCF3-Pyridin-2-amine; 2-Amino-5-(trifluoromethylsulfanyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethylsulfanyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.