Description

6-(Trifluoromethylthio)Pyridin-3-Amine is a high-purity, functionalized pyridine derivative characterized by its trifluoromethylthio (-SCF₃) substituent. This compound is a critical pharmaceutical intermediate and agrochemical building block, valued for its ability to modulate the physicochemical properties of target molecules, enhancing metabolic stability and lipophilicity. It is primarily utilized by R&D chemists and process development scientists in the life sciences and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the -SCF₃ group contributes to biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production under cGMP guidelines.

Basic Information

Item	Detail
Product Name	6-(Trifluoromethylthio)Pyridin-3-Amine
CAS No.	1153767-25-9
Molecular Formula	C₇H₅F₃N₂S
Molecular Weight	206.19 g/mol
Synonyms	3-Amino-6-(trifluoromethylthio)pyridine; 6-(Trifluoromethylsulfanyl)pyridin-3-amine; 5-Amino-2-(trifluoromethylthio)pyridine; 2-(Trifluoromethylthio)-5-aminopyridine; Pyridine, 3-amino-6-[(trifluoromethyl)thio]-; 1153767-25-9; 6-(Trifluoromethylmercapto)pyridin-3-amine
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethylthio)Pyridin-3-Amine is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring compliance with customer specifications and ICH guidelines for pharmaceutical intermediates. Our quality commitment supports regulatory filings for markets globally, including those requiring REACH and TSCA compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.