Description

(-)-Sesamin 2,2'-Diol is a high-purity, optically active lignan derivative, a key intermediate in the synthesis of complex bioactive molecules. Its significance lies in its role as a critical chiral building block for pharmaceutical research and development, particularly in creating novel therapeutic agents. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, nutraceutical, and fine chemical industries seeking to develop new drug candidates or study structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral precursor for the synthesis of novel drug candidates targeting various therapeutic areas.
• Biochemical Research: Used as a reference standard or probe in metabolic pathway studies and enzyme interaction research due to its specific stereochemistry.
• Nutraceutical Development: Acts as a high-purity starting material for the development of advanced dietary supplements and functional food ingredients.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce enantioselectivity.
• Natural Product Analog Synthesis: Used to create synthetic analogs of sesamin and related lignans for biological evaluation and patentable novel chemical entities.
• Process Chemistry: Integral in scaling up synthetic routes for bioactive lignans under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	(-)-Sesamin 2,2'-Diol
CAS No.	1152441-87-6
Molecular Formula	C20H18O6
Molecular Weight	354.35 g/mol
Synonyms	(-)-2,2'-Dihydroxysesamin; (7'R,8'R,7S,8S)-4,4',7,7',8,8'-Hexahydro-6,6',7,7'-tetramethoxy-2,2'-binaphtho[1,8-bc]furan-4,4'-diol; Sesamin Diol; Lignan Diol; 2,2'-Bis(hydroxysesamin); (-)-Sesamin-2,2'-diol; AS 2,2'-Diol
EINECS	Contact for details

Quality Control

Our (-)-Sesamin 2,2'-Diol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. We adhere to relevant quality management standards to support its use in research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.